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A macrophage migration-inhibition test was negative in the presence of both quinidine and allopurinol. However, allopurinol did not cause birth defects or other problems in rats or rabbits given doses up to 20 times the amount usually given to humans. If you are or will be breast-feeding while you use Allopurinol , check with your doctor. In one study in mice, large amounts of allopurinol caused birth defects and other unwanted effects. You will need to discuss the benefits and risks of using Allopurinol  while you are pregnant.

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